Application | Comment | Organism |
---|---|---|
medicine | TYMS is the target enzyme of fluorouracil, an antimetabolite widely used in the treatment of colorectal, head-and-neck, breast cancers, pancreatic cancer and hepatocellular carcinoma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-fluorouracil | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate | 7,8-dihydrofolate + dTMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | NCI60 panel of 60 human tumor cell lines, the NCI-60 model is able to provide interesting information about the role of TYMS gene polymorphisms on TYMS mRNA expression and catalytic activity | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | it is a key enzyme for the synthesis of the DNA-specific nucleotide thymidylate | Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TYMS | - |
Homo sapiens |